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KMID : 0388219940010020221
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Journal of the Korean Rheumatism Association
1994 Volume.1 No. 2 p.221 ~ p.231
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Expression of IGF-1 and TGF-β in Rheumatoid Arthritis and Osteoarthritis
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이인호
정성수/배상철/유대현 김성윤/정형기/최일용
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Abstract
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Objective :
@EN In normal tissue a stable eqqulibrium between the synthesis and degradation of matrix components, is maintained. It is of interest to understand the influence of local growth factors, such as IGF-I(insulin-like growth factor-I) and TGF-β on
this
equilbrium.
IGF-I is a polypeptide with functional and structural homology to proinsulin. IFG-I plays a part in the growth and development of many tissues during fetal and adult stage, and is implicated in tissue hypertrophy and repair.
TGF-βis a multipotent regulator of cell growth and extracellular matrix synthesis. TGF-βhas a biphasic effect on proteoglycan synthesis and cell proliferation.
The aim of our study was to determine whether the IGF-I and TGF-β were expressed by human synovial tissue and articular chondrocytes.
@ES methods :
@EN Immunohistochemical analysis regarding the expression of IGF-I and TGF-βin articular cartilage and synovial tissue was conducted using monoclonal antibody and avidin biotin complex method.
@ES Results : the results were as follows ;
@EN 1) The expression of IGF-I and TGF-βin synovial tissue was diffuse and intense at synovial lining cells, endothelral cells and infiltrating inflammatory cells. But the stain of IGF-I protein was distributed unevenly in the synovial tissue.
Expression of these two growth factors in rheumatoid arthritis synovium was higher than that in osteoarthritis tissue.
2) The expression of IGF-I and TGF-β in arthicular cartilage was strong at chondrocytes and the intensity of staining was strong especially at cluster of chondrocytes.
3) in cartilage-pannus junction, TGF-β containing cells were detected throughout the pannus area. The stain of IGF-I protein was seen in a similar distribution pattern to that in cartilage-pannus junction. These observations suggest that
locally
produced IGF-I and TGF-βhave specific roles in the synovial pannus formation site.
@ES Conclusion :
@EN These observations suggest that locally produced IGF-I and TGF-βhave specific roles in the lesions of articular cartilage and synovial tissue. Further prospective in the field of IGF-I and TGF-βmay be the identification of exact process of
intracellular signalling and regulation of expredssion by other cytokines and grwoth factors.
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KEYWORD
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